While I have flown over the Sierras and Cascades a bunch of times, I have only landed at a few high altitude airports in the summer time. When I took off from Lake Tahoe and Jackson Hole I had an experienced mountain flyer with me and was flying a normally aspirated Cessna 182. We followed the techniques in this video and takeoff was interesting. It was fun to catch a mountain wave on the way out of Tahoe and gain quite a bit of altitude in a short time. Taking off from Durango, Colorado in a turbocharged Cessna 210 was not much different from taking off from my near sea-level home field. Just a longer takeoff roll.